C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2453381
The present invention is directed to methods for readily propagating somatic tissue stem cells ex vivo. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses assymmetric cell kinetics in the explanted tissue cells. The methods of the invention include pharmacological methods and genetic methods. The resulting cultured somatic stem cells can be used for a variety of applications including cell replacement therapies such as bone marrow transplants, gene therapies, tissue engineering, and in vitro organogenesis.
La présente invention concerne des procédés permettant une propagation facile ex vivo de cellules souches de tissus somatiques. Ce procédé fait intervenir un renforcement de la biosynthèse des nucléotides de guanine (GNP), ce qui développe les groupes de nucléotides de guanine et supprime par voie de conséquence de façon conditionnelle la cinétique des cellules asymétriques dans les cellules des tissus explantés. Les procédés de l'invention regroupent des procédés pharmacologiques et des procédés génétiques. Les cellules souches somatiques ainsi cultivées conviennent particulièrement pour diverses applications, et notamment les thérapies à remplacement de cellules telles que les greffes de moelle osseuse, les thérapies géniques, le génie tissulaire, et l'organogenèse in vitro.
Gowling Lafleur Henderson Llp
Massachusetts Institute Of Technology
LandOfFree
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