Methods for extracting substances using alternating current

Details Methods for extracting substances using alternating current Methods for extracting substances using alternating current

A - Human Necessities

61

N

A61N 1/32 (2006.01)

Patent

CA 2400074

A variety of methods for extracting different substances such as endogenous substances, pharmaceutical substances, markers of disease, and their metabolites across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which extraction occurs, thereby allowing substances to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be utilized to assist in promoting extraction of the substance. The methods have utility in a variety of different clinical settings and applications.

La présente invention concerne divers procédés d'extraction de différentes substances, telles que des substances endogènes, des substances pharmaceutiques, des marqueurs de maladie et leurs métabolites, à travers un tissu. Ces procédés utilisent un signal en courant alternatif, afin de maintenir un état électrique sensiblement constant dans une région du tissu à travers lequel l'extraction a lieu, ce qui permet aux substances d'être transportées à travers le tissu de manière commandée et prévisible. Certains procédés comprennent un signal optionnel de pré-impulsion en courant alternatif ou continu, afin d'atteindre l'état électrique cible au départ. Un signal optionnel de compensation en courant continu peut également être utilisé, afin d'aider à favoriser l'extraction de la substance. Les procédés selon cette invention peuvent être utilisés dans une variété d'installations et d'applications cliniques.

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