C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 30/04 (2006.01)
Patent
CA 2563087
This invention relates generally to the production of human neuronal cells from human embryonic stem cells and/or human neuronal progenitor cells. In some embodiments, the human neuronal cells are neural crest cells. In other embodiments, the human neuronal cells are peripheral neurons. In other embodiments, the human neuronal cells are schwann cells. The invention provides methods of culturing and purifying human neuronal cells and uses thereof. Such uses include generating models of neuropathy, drug screening methods, and cell based therapeutic.
La présente invention concerne globalement la production de cellules neuronales humaines à partir de cellules souches embryonnaires humaines et/ou de cellules progénitrices neuronales humaines. Dans certains modes de réalisation, les cellules neuronales humaines sont des cellules de la crête neurale. Dans d'autres modes de réalisation, les cellules neuronales humaines sont des neurones périphériques. Dans d'autres modes de réalisation, les cellules neuronales humaines sont des cellules de Schwann. L'invention concerne également des méthodes destinées à la culture et à la purification de cellules neuronales humaines et à leurs applications. Ces applications comprennent la production de modèles de neuropathie, des méthodes de criblage de médicaments, ainsi que des thérapies cellulaires.
Goldstein Ronald S.
Reubinoff Benjamin
Goldstein Ronald S.
Gowling Lafleur Henderson Llp
Reubinoff Benjamin
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