C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01) C07K 16/10 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2680613
This invention generally relates to methods for the production of antibody producing cells and antibodies in protooncogene expressing animals. The invention also relates to methods for the efficient production of antibodies specific for antigens that are normally subject to immunological constraints such as self tolerance. The invention further relates to the production of antibody producing cells and antibodies without the need for the conventional fusing of antibody producing B cells with a myeloma fusion partner.
La présente invention concerne de manière générale des procédés de production de cellules produisant des anticorps et des anticorps chez des animaux exprimant un protooncogène. L'invention concerne des procédés de production efficace d'anticorps spécifiques d'antigènes qui sont normalement sujets à des contraintes immunologiques telles qu'une auto-tolérance. L'invention concerne en outre la production de cellules produisant des anticorps et des cellules sans nécessiter de fusion classique de lymphocytes B produisant des anticorps avec un partenaire de fusion de myélome.
Refaeli Yosef
Turner Brian Curtis
National Jewish Health
National Jewish Medical And Research Center
Smart & Biggar
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