Methods for global profiling gene regulatory element activity

Details Methods for global profiling gene regulatory element activity Methods for global profiling gene regulatory element activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2439312

The present disclosure provides methods for profiling, in a global manner, the activity of gene regulatory elements in cells, preferably eukaryotic and prokaryotic cells. The methods include use of Fluorescence Polarization and other homogeneous assays, regulatory element activity profiling (REAP), and electrophoretic mobility shift assays. Cells may be in any state of metabolism, whether resting, growing, normal, mutant, diseased or differentiating.

L'invention concerne des procédés de profilage, de manière générale, de l'activité d'éléments régulateurs d'un gène dans des cellules, de préférence des cellules eucaryotes et procaryotes. Ces procédés consistent à utiliser la polarisation de fluorescence et d'autres analyses homogènes, le profilage d'activité d'élément régulateur (REAP) et des analyses de modification de la mobilité électrophorétique. Les cellules peuvent se trouver dans un état quelconque de métabolisme, au repos, en développement, normal, mutation, malade ou en cours de différenciation.

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