Methods for global profiling gene regulatory element activity

Details Methods for global profiling gene regulatory element activity Methods for global profiling gene regulatory element activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2565005

The present invention provides methods for profiling, in a global manner, the activity of gene regulatory elements in cells, including eukaryotic and prokaryotic cells. The methods involve analysis of regulatory element complexes formed under cell-free conditions or within cells (sometimes called "in vivo"). In accordance with the invention, cells can be in any state of metabolism, resting, growing, normal, mutant, diseased or differentiating. The gene regulatory element activity profiles generated for the cells in different cell populations are compared to determine differences in gene regulatory activity and overall gene expression between or among different types or states of cells.

La présente invention concerne des méthodes de profilage global de l'activité d'éléments de régulation géniques dans des cellules, y compris des cellules eucaryotes et procaryotes. Ces méthodes consistent à analyser des complexes d'éléments de régulation dans des conditions non cellulaires ou dans des cellules ("in vivo"). Selon l'invention, les cellules peuvent se trouver dans un quelconque état métabolique, au repos, en croissance, à l'état normal, en mutation, malades ou en différenciation. Les profils d'activité des éléments de régulation génique générés pour les cellules dans différentes populations de cellules sont comparés afin de déterminer les différences d'activité de régulation génique et d'expression génique globale entre ou parmi différents types ou états cellulaires.

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