Methods for glucagon suppression

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 5/48 (2006.01) A61P 35/00 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2356331

Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for lowering glucagon levels and/or suppressing glucagon secretion in a subject are provided. These methods are useful in treating hyperglucagonemia and other conditions that would be benefited by lowering plasma glucagon or suppressing glucagon secretion.

L'invention concerne des méthodes d'utilisation d'une exendine, d'un agoniste d'exendine, ou d'une exendine ou d'un agoniste d'exendine modifié dont une exendine ou un agoniste d'exendine est lié à un ou plusieurs polymères de polyéthylène glycol, de manière, par exemple, à abaisser les taux de glucagon et/ou supprimer la sécrétion de glucagon chez un sujet. Ces méthodes sont utiles pour traiter l'hyperglucagonémie et autres états pour lesquels la réduction du taux de glucagon dans le plasma ou la suppression de la sécrétion de glucagon pourraient être bénéfiques.

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