Methods for humanizing antibodies and humanized antibodies...

Details Methods for humanizing antibodies and humanized antibodies... Methods for humanizing antibodies and humanized antibodies...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12P 21/04 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2647380

Disclosed herein is the use of three-dimensional structure information to guide the process of modifying antibodies with amino acids from one or more templates or surrogates such that the antigen binding properties of the parent antibody are maintained and the immunogenicity potential is reduced when administered as a therapeutic in humans.

L'invention concerne l'utilisation d'informations de structures tridimensionnelles dans l'orientation du processus de modification d'anticorps au moyen d'acides aminés provenant d'au moins une matrice ou substitut, de sorte que les propriétés de liaison antigénique de l'anticorps parent soient préservées et que le potentiel d'immunogénicité soit réduit lorsque ces anticorps sont administrés comme agents thérapeutiques à des humains.

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