C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/7088 (2006.01) A61K 38/12 (2006.01) A61K 38/16 (2006.01) A61K 45/00 (2006.01) A61P 5/50 (2006.01) C12Q 1/34 (2006.01) C12Q 1/44 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2487856
The present invention relates to methods for identifying agents useful for alleviating insulin resistance in mammals, said methods being enabled by the finding that the insulin receptor substrate 1 (IRS-1) and histone deacetylase 2 (HDAC2) physically interact. By inhibition of the deacetylase activity in this complex, the insulin sensitivity can be restored.
L'invention concerne des méthodes d'identification d'agents utiles pour l'atténuation de la résistance à l'insuline chez les mammifères, méthodes rendues possibles par la découverte de l'interaction physique entre le substrat 1 du récepteur de l'insuline (IRS-1) et l'histone désacétylase. L'inhibition de l'activité de la désacétylase dans ce complexe permet de rétablir la sensibilité à l'insuline.
James Stephen
Kaiser Christina
Biovitrum Ab
Fetherstonhaugh & Co.
LandOfFree
Methods for identification of compounds modulating insulin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for identification of compounds modulating insulin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identification of compounds modulating insulin... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1993788