C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/87 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2370803
Methods are disclosed whereby inhibition of proteolytic activity causes an increase in delivery of a transferable label from a viral display package to a target cell. Assaying for the transferable label in the target cell in the presence of a test substance can identify the test substance as a protease inhibitor. Protease inhibitors so identified are used therapeutically, to treat conditions such as cancer, inflammation, rheumatoid arthritis and other autoimmune diseases, and infections, including AIDS, herpes, and hepatitis.
L'invention concerne des méthodes selon lesquelles l'inhibition de l'activité protéolytique augmente la distribution d'une étiquette transférable d'une capside d'exposition virale à une cellule cible. Un dosage permettant de détecter l'étiquette transférable dans la cellule cible en présence d'une substance d'essai peut identifier cette substance d'essai comme étant un inhibiteur de protéase. Les inhibiteurs de protéase ainsi identifiés ont une utilité thérapeutique dans le traitement d'états pathologiques tels que le cancer, l'inflammation, la polyarthrite rhumatoïde et d'autres maladies auto-immunes ainsi que des infections, notamment le sida, l'herpès et l'hépatite.
Chadwick Mark P.
Russell Stephen J.
Biofocus Discovery Limited
Cambridge Drug Discovery Ltd.
Torys Llp
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