Methods for identifying agents, which regulate cytokines

Details Methods for identifying agents, which regulate cytokines Methods for identifying agents, which regulate cytokines

G - Physics

01

N

G01N 33/569 (2006.01) A61K 38/30 (2006.01) C07K 16/24 (2006.01) C12N 15/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2528281

The present invention relates to methods for identifying agents that modulate the effect of cytokine class I receptor binding compounds, by inhibiting the interaction between the cytokine class I receptor and nuclear factors. The agents are useful for decreasing IGF-1 levels in a cell, and for the treatment of medical disorders caused by hormone dysregulation, such as growth hormone or prolactin dysregulation.

L'invention concerne un procédé pour identifier des agents qui modulent l'effet des composés de liaison du récepteur de classe I de la cytokine, par inhibition de l'interaction entre le récepteur de classe I de la cytokine et des facteurs nucléaires. Lesdits agents sont utilisés pour diminuer les taux de l'IGF-1 dans une cellule, et pour traiter des troubles médicaux provoqués par un dérèglement hormonal, tel qu'un dérèglement de l'hormone de croissance ou de la prolactine.

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