C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/04 (2006.01) C12Q 1/24 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2441571
The present invention relates to purified smooth muscle progenitor cells and a method for isolating such cells. The purified smooth muscle progenitor cells of the present invention are capable of being induced into the smooth muscle cell lineage at high efficacy (i.e. greater than 60% conversion). The method comprises the steps of transforming cell populations that contain totipotent or pluripotent cells with DNA constructs that are expressed only in the smooth muscle cell lineage, inducing a portion of those cells and identifying those cells that express the construct only after the cells are induced.
La présente invention concerne des cellules souches de muscle lisse purifiées et un procédé permettant d'isoler de telles cellules. Les cellules souches de muscle lisse décrites dans cette invention peuvent être introduites dans une lignée cellulaire de muscle lisse avec une efficacité élevée (c'est-à-dire plus de 60 % de conversion). Le procédé comprend les étapes consistant à transformer les populations cellulaires contenant des cellules totipotentes ou multipotentes avec des constructions d'ADN qui sont exprimées uniquement dans la lignée cellulaire de muscle lisse, à introduire une portion de ces cellules, puis à identifier les cellules exprimant cette construction uniquement après l'introduction desdites cellules.
Manabe Ichiro
Owens Gary K.
Fetherstonhaugh & Co.
University Of Virginia Patent Foundation
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