Methods for identifying and validating potential drug targets

Details Methods for identifying and validating potential drug targets Methods for identifying and validating potential drug targets

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C12Q 1/25 (2006.01) C12Q 1/70 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G06F 17/30 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2468107

This application provides methods for identifying and validating potential drug targets. In one aspect, the application provides a systematic method of creating a database of related protein or nucleic acid sequences with annotations of the potential disease associations of the sequences; and a method for testing the potential disease associations by means of a biological assay and validating the disease association by either decreasing expression of the sequence of interest or increasing expression of the sequence of interest.

La présente invention concerne des procédés pour identifier et valider des cibles de médicament potentielles. Un aspect de cette invention concerne un procédé systématique pour créer une base de données de séquences de protéines ou d'acides nucléiques associés, avec des annotations concernant des associations potentielles des séquences à des maladies, ainsi qu'un procédé pour tester les associations potentielles à des maladies au moyen d'un dosage biologique et pour valider cette association à des maladies en diminuant l'expression de la séquence cible ou en augmentant l'expression de la séquence cible.

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