C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2323932
Methods are provided for identifying agents that modulate the expression of genes, such as genes encoding tumor suppressor or tumor-promoting proteins. The methods generally comprise screening candidate agents for the ability to enhance expression of a tumor suppressor gene, such as mda-7, or for the ability to inhibit expression of a tumor-promoting gene within a cell. Modulating agents may be used, for example, within anti-cancer therapies.
L'invention porte sur des procédés d'identification d'agents modulant l'expression de gènes tels que des gènes codant pour des suppresseurs de tumeurs ou des protéines promotrices de tumeurs. Lesdits procédés consistent de manière générale à cribler les agents candidats capables de renforcer l'expression d'un gène suppresseur de tumeur tel que le mda-7, ou d'inhiber l'expression d'un gène promoteur de tumeurs à l'intérieur d'une cellule. Les agents modulateurs peuvent par exemple être utilisés dans le cadre de thérapies anticancéreuses.
Fisher Paul B.
Goldstein Neil I.
Sun Yilong
Chinook Acquisition Corporation
Fisher Paul B.
Goldstein Neil I.
Gowling Lafleur Henderson Llp
Sun Yilong
LandOfFree
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