G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 21/35 (2006.01)
Patent
CA 2309945
Methods for determining whether a biological macromolecule binds to a compound. The methods comprise the steps of: a) obtaining an FT-IR spectrum of a solution comprising a biological macromolecule and obtaining an FT-IR spectrum of a solution comprising a compound; b) obtaining an FT-IR spectrum of a solution comprising a mixture of the biological macromolecule and the compound; c) subtracting the FT-IR spectrum of the individual biological macromolecule and compound from the FT-IR spectrum of the mixture to determine a subtracted index; and d) identifying a compound that binds to the biological macromolecule when the subtracted index of step c) is not equal to about 0.
L'invention porte sur des procédés visant à déterminer si une macromolécule biologique se lie à un composé. Ces procédés consistent à: a) obtenir un spectre infrarouge à transformée de Fourier d'une solution comprenant une macromolécule biologique et un spectre d'une solution comprenant un composé; b) obtenir un spectre infrarouge à transformée de Fourier d'une solution comprenant un mélange de la macromolécule biologique et du composé; c) soustraire le spectre de la macromolécule biologique individuelle et du composé du spectre du mélange de façon à déterminer un indice soustrait; et d) identifier un composé qui se lie à la macromolécule biologique lorsque l'indice soustrait de l'étape c) n'est pas égal à 0.
Bruening Reimar C.
Marshall Shannon
Millennium Pharmaceuticals Inc.
Smart & Biggar
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