Methods for identifying cells suitable for large-scale...

Details Methods for identifying cells suitable for large-scale... Methods for identifying cells suitable for large-scale...

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2716801

The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high- throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding the protein of interest indicates that the cell is suitable for large-scale production of the protein of interest.

Linvention concerne des procédés didentification dune population clonale de cellules appropriées pour une production à grande échelle dune protéine dintérêt. Linvention concerne en outre des procédés de criblage de haute capacité pour des réarrangements génétiques dans le gène codant la protéine dintérêt, de sorte que labsence dune délétion dans le gène codant la protéine dintérêt indique que la cellule est appropriée pour une production à grande échelle de la protéine dintérêt.

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