C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 21/00 (2006.01) C07K 16/28 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2439170
Screening methods for identifying compounds that bind to or activate corticotropin releasing factor2 receptors (CRF2R) and regulate or potentially regulate skeletal muscle mass or function in vivo. Also disclosed are screening methods for identifying compounds that prolong or augment the activation of CRF2Rs or of CRF2R signal transduction pathways, increase CRF2R or increase CRF expression are provided. Pharmaceutical compositions comprising CRF2R agonists, antibodies to CRF2R and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using CRF2R as the target for intervention and methods for treatment of muscular dystrophies are described.
La présente invention concerne des procédés de criblage permettant d'identifier des composés qui se lient ou qui activent les récepteurs de la corticolibérine ¿2? (CRF¿2?R) et qui régulent ou peuvent réguler in vivo la fonction ou la masse musculaire du squelette. Cette invention concerne également des procédés de criblage permettant d'identifier des composés qui prolongent ou qui augmentent l'activation des voies de transduction des CRF2Rs ou des signaux de CRF2R, ou qui augmentent l'expression de CRF2R ou de CRF. La présente invention concerne également des compositions pharmaceutiques comprenant des agonistes CRF2R, des anticorps dirigés contre CRF2R, ainsi que des méthodes permettant d'augmenter la fonction ou la masse musculaire du squelette, ou de traiter l'atrophie des muscles du squelette, au moyen de CRF2R en tant que cible d'intervention, ainsi que des méthodes permettant de traiter des dystrophies musculaires.
Isfort Robert Joseph
Sheldon Russell James
The Procter & Gamble Company
Torys Llp
Warner Chilcott Company Llc
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