C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2430746
The invention provides a method of identifying a compound that modulates a disease associated with a nitric oxide/cGMP-dependent protein kinase network in a mammal. The method consists of (a) ad ministering a test compound to an invertebrate; and (b) measuring a foraging behavior of the invertebrate, wherein a compound that modulates the foraging behavior of the invertebrate is characterized as a compound that modulates a disease associated with a nitric oxide/cGMP-dependent protein kinase network in a mammal.
L'invention concerne un procédé d'identification d'un composé qui module une maladie associée à un réseau de protéines kinases dépendantes d'oxyde nitrique/GMP cyclique chez un mammifère. Le procédé consiste à : (a) administrer un composé test à un invertébré ; et (b) mesurer un comportement de recherche de nourriture de l'invertébré. Un composé qui module le comportement de recherche de nourriture de l'invertébré est caractérisé comme composé modulant une maladie associée à un réseau de protéines kinases dépendantes d'oxyde nitrique/GMP cyclique chez un mammifère.
Greenspan Ralph J.
Shaw Paul J.
Neurosciences Research Foundation Inc.
Smart & Biggar
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