Methods for identifying differentially expressed genes by...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2463622

The present invention applies pattern recognition and multidimensional classification in statistical microarray data analysis. There are provided methods for identifying a subset of genes that are differentially expressed under a given biological state or at a given biological locale of interest by determining an advantageously large probability distance between the random vectors representing expression levels of the genes of interest. The invention also provides a cross-validated random search mechanism for a subset of genes based on various probability distances between two random vectors.

La présente invention se rapporte à la reconnaissance de formes et la classification multidimensionnelle dans l'analyse statistique de données de micropuces. L'invention concerne des procédés permettant d'identifier un sous-ensemble de gènes qui sont exprimés de manière différentielle dans un état biologique donné ou sur un site biologique d'intérêt en déterminant une distance de probabilité avantageusement grande entre les vecteurs aléatoires représentant les niveaux d'expression des gènes d'intérêt. L'invention se rapporte également à un mécanisme de recherche aléatoire à validation croisée pour un sous-ensemble de gènes, qui se base sur différentes distances de probabilité entre deux vecteurs aléatoires.

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