Methods for identifying hot-spot residues of binding...

Details Methods for identifying hot-spot residues of binding... Methods for identifying hot-spot residues of binding...

G - Physics

01

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G01N 33/53 (2006.01) C07C 229/00 (2006.01) C07D 311/82 (2006.01) C12Q 1/37 (2006.01) G01N 23/00 (2006.01) G01N 33/00 (2006.01) G01N 33/536 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2347419

The present invention provides methods of identifying hot-spot residues for one or both members of a receptor-ligand complex of interest. Further provided are methods of using receptor hot-spot residues to identify compounds that functionally bind a receptor in a manner that mimics the binding of a known ligand for the receptor.

La présente invention concerne des procédés d'identification applicables à des résidus de point chaud pour un seul ou les deux éléments d'un complexe d'intérêt récepteur-ligand. Elle concerne également des techniques d'utilisation de résidus de point chaud de récepteur pour identifier des composés dont la liaison fonctionnelle avec un récepteur rappelle la liaison d'un ligand connu audit récepteur.

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