Methods for identifying inhibitors of rna viruses

Details Methods for identifying inhibitors of rna viruses Methods for identifying inhibitors of rna viruses

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) C07K 14/18 (2006.01) C12Q 1/25 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2244372

Assay methods are disclosed having utility in the identification of therapeutic agents effective against human hepatitis C virus and related viruses. NS3 protein derived from these viruses, representing a native and authentic version of the complete protein sequence, is used in the assay methods of the invention, which enables identification and development of anti- viral agents exhibiting inhibition of the protein's NTPase and RNA helicase activities.

L'invention concerne des tests utiles pour l'identification d'agents thérapeutiques efficaces contre le virus de l'hépatite C humaine et contre des virus connexes. La protéine NS3 dérivée de ces virus représente une version naturelle et authentique de la séquence protéique complète et elle est utilisée dans les tests de l'invention, pour identifier et mettre au point des agents anti-viraux, capables d'inhiber les activités NTPase et ARN-hélicase de la protéine.

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