C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2251744
A method of diagnosing a disease associated with a genetic polymorphism in a vitamin D receptor gene comprises determining the genotype of said vitamin D receptor gene in an animal. The method can be used to diagnose predisposition or susceptibility to osteoarthritis. Compositions for said diagnosis are provided. Methods of treatment of osteoarthritis are provided, comprising identifying an individual having a predisposition or susceptibility to the disease and subsequently treating that individual.
La présente invention concerne un procédé permettant de diagnostiquer une maladie associée à un polymorphisme génétique dans un gène récepteur de la vitamine D chez l'animal, et de déterminer le génotype dudit gène. Ce procédé peut être utilisé pour diagnostiquer la prédisposition à l'arthrose. Des compositions servant à établir ce diagnostic sont décrites, ainsi que des méthodes de traitement de l'arthrose, y compris d'identification et de traitement d'un sujet prédisposé à cette maladie.
Keen Richard William
Spector Timothy David
Gemini Research Ltd.
Goudreau Gage Dubuc
Sequenom-Gemini Limited
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