Methods for identifying risk of osteoarthritis and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2561669

Provided herein are methods for identifying a risk of osteoarthritis in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating osteoarthritis, and therapeutic and preventative methods applicable to osteoarthritis. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

La présente invention a trait à des procédés d'identification d'un risque d'ostéoarthrite chez un sujet, à des réactifs et des trousses pour la mise en oeuvre des procédés, à des procédés d'identification d'agents thérapeutiques candidats pour le traitement d'ostéoarthrite, et à des procédés thérapeutiques et préventifs applicables à l'ostéoarthrite. Ces modes de réalisation sont basés sur une analyse des variations polymorphes dans des séquences nucléotidiques au sein du génome humain.

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