C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/7105 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2497597
Provided herein are methods for identifying risk of melanoma in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for frosting melanoma, and therapeutic methods for treating melanoma in a subject. These embodiments are based upon an analysis of polymorphic variations in a BRAF nucleic acid, which has a nucleotide sequence exemplified by SEQ ID NO:1.
L'invention concerne des procédés d'identification de risque de mélanome chez un sujet, des réactifs et des kits pour la mise en oeuvre des procédés, ainsi que des procédés permettant d'identifier des moyens thérapeutiques envisageables pour le traitement du mélanome, et des procédés thérapeutiques pour le traitement d'un sujet atteint. Ces variantes reposent sur l'analyse de variations polymorphes au sein d'un acide nucléique BRAF, à séquence nucléotidique représentée dans l'exemple SEQ ID NO:1.
Braun Andreas
Nelson Matthew Roberts
Roth Richard B.
Braun Andreas
Nelson Matthew Roberts
Roth Richard B.
Sequenom Inc.
Smart & Biggar
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