Methods for imaging dopamine transporter level

Details Methods for imaging dopamine transporter level Methods for imaging dopamine transporter level

A - Human Necessities

61

K

A61K 51/04 (2006.01)

Patent

CA 2700468

Presented is a method for assessing dopamine transporter levels in a selected area of a subject's central nervous system by SPECT imaging comprising administering an injection of a labeled dopamine transporter ligand at approximately the time the subject is positioned for SPECT imaging and initiating a SPECT acquisition for a duration of about 30 minutes commencing at about 15 minutes after administration of labeled dopamine transporter ligand; and assessing, based on said SPECT acquisition, the amount of labeled dopamine transporter ligand that is bound to dopamine transporter.

L'invention concerne un procédé pour évaluer les niveaux du transporteur de la dopamine dans une zone sélectionnée du système nerveux central d'un sujet par imagerie SPECT, comprenant les étapes consistant à administrer une injection d'un ligand marqué du transporteur de la dopamine, approximativement au moment où le sujet est positionné pour une imagerie SPECT, et lancer une acquisition SPECT pour une durée d'environ 30 minutes en commençant environ 15 minutes après l'administration du ligand marqué du transporteur de la dopamine; et estimer, sur la base de ladite acquisition SPECT, la quantité de ligand marqué du transporteur de la dopamine qui se lie au transporteur de la dopamine.

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