Methods for improved engraftment following stem cell...

A - Human Necessities – 61 – K

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A61K 35/14 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2668673

The present invention relates to methods repairing, regenerating, and reconstituting tissues by transplanting at least two stem cell populations, wherein the first and the second population of stem cells are introduced into a subject separated by a time interval of about 2 to about 24 hours. The stem cells can be derived from umbilical cord, mobilized peripheral blood, or bone marrow. The cells of at least the second population may be enriched for adult stem and progenitor cells. The methods of the invention are useful in accelerating hematopoeitic recovery in subjects following myeloablation or chemotherapy.

La présente invention concerne des méthodes de réparation, de régénération et de reconstitution des tissus par transplantation d'au moins deux populations de cellules souches, lesdites première et seconde populations de cellules souches étant introduites dans le corps d'un sujet à un intervalle compris entre environ 2 et 24 heures. Ces cellules souches peuvent être dérivées du cordon ombilical, du sang périphérique mobilisé ou de la moelle épinière. Les cellules de la seconde population au moins peuvent être enrichies pour des cellules souches et progénitrices adultes. Les méthodes de l'invention sont utiles pour accélérer la récupération hématopoïétique chez des sujets après une myéloablation ou une chimiothérapie.

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