Methods for improving bioavailability of a renin inhibitor

Details Methods for improving bioavailability of a renin inhibitor Methods for improving bioavailability of a renin inhibitor

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61K 38/13 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2572743

The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a .delta.-amino-.gamma.-hydroxy-.omega.-aryl- alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of a renin inhibitor, or a pharmaceutically acceptable salt thereof, and an efflux protein inhibitor.

Cette invention concerne un procédé pour améliorer la biodisponibilité d'un inhibiteur de rénine, de préférence d'un dérivé d'acide d-amino-?-hydroxy-?-aryl-alcanoïque, ce procédé consistant à administrer conjointement à un mammifère, notamment un sujet humain, nécessitant un tel traitement, une combinaison d'un inhibiteur de rénine, ou un sel de celui-ci acceptable sur le plan pharmaceutique, et d'un inhibiteur de protéines d'efflux.

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