Methods for improving drug disposition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/00 (2006.01) A61K 31/4196 (2006.01) A61P 7/00 (2006.01) A61P 25/00 (2006.01) A61P 39/04 (2006.01)

Patent

CA 2597332

The invention provides a method for improving the bioavailability, preferably, oral bioavailability and/or drug disposition, e.g. brain penetration, of an iron chelator, which method comprises co-administering to a mammal, especially a human, in need of such treatment, a combination of an iron chelator and an efflux protein inhibitor.

L'invention concerne un procédé permettant d'améliorer la biodisponibilité, de préférence, la biodisponibilité orale et/ou le sort de médicaments, par exemple la pénétration d'un chélateur du fer dans le cerveau, lequel procédé comprend l'administration concomitante d'un chélateur du fer et d'un inhibiteur de l'efflux des protéines à un mammifère, particulièrement à un humain, requérant ce type de traitement.

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