Methods for improving neurological outcome after neural...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2756574

Thymosin .beta.4 can be used to treat neuronal and brain injuries that are accompanied by neuronal cell death or injury, including injuries caused by stroke or trauma and injuries caused by neurological and neurodegenerative disease. In particular, stroke and multiple sclerosis are examples of conditions which may be ameliorated by treatment with thymosin .beta.4. Thymosin .beta.4 has been found to restore neurological tissue through several effects on several neurological parameters which are improved by administration of thymosin .beta.4 to a subject in need of neurological tissue restoration. For example, thymosin .beta.4 improves axonal myelination, migration of neural progenitor cells, neural progenitor cell proliferation, differentiation of neural progenitor cells into mature neurons, differentiation of neural progenitor cells into mature glia, nerve regeneration, and brain remodeling at locations of brain injury.

La thymosine ß4 peut être utilisée pour traiter des lésions neuronales et du cerveau qui sont accompagnées de la mort ou de lésions des cellules neuronales, y compris des lésions causées par un accident vasculaire cérébral ou un traumatisme et des lésions causées par une maladie neurologique et neurodégénérative. En particulier, l'accident vasculaire cérébral et la sclérose en plaques sont des exemples d'états pathologiques qui peuvent être améliorés par un traitement avec la thymosine ß4. La thymosine ß4 s'est avérée restaurer les tissus neurologiques par le biais de plusieurs effets sur plusieurs paramètres neurologiques qui sont améliorés par l'administration de la thymosine ß4 à un sujet qui a besoin d'une restauration des tissus neurologiques. Par exemple, la thymosine ß4 améliore la myélinisation des axones, la migration des cellules progénitrices neurales, la prolifération des cellules progénitrices neurales, la différenciation des cellules progénitrices neurales en neurones matures, la différenciation des cellules progénitrices neurales en cellules gliales matures, la régénération des nerfs, et le remodelage du cerveau aux emplacements de la lésion du cerveau.

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