Methods for improving viability and productivity in cell...

Details Methods for improving viability and productivity in cell... Methods for improving viability and productivity in cell...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/071 (2010.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2727010

Methods are disclosed for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture by overexpressing a D300A mutant of MDM2 in the cells.

L'invention porte sur des procédés pour augmenter la viabilité et la production de protéines sécrétées dans une culture de cellules eucaryotes à alimentation discontinue.

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