Methods for improving viral vector titers and reducing cell...

Details Methods for improving viral vector titers and reducing cell... Methods for improving viral vector titers and reducing cell...

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2389057

Disclosed are compositions and methods for the increasing the production of a recombinant viral vector in a cell culture, comprising culturing a recombinant viral vector producing cell line in a basal media which further comprises (a) greater than 1.5 g/L amino acids (or, a selected amino acids in a quantity and amount greater than present in a basal media such as DMEM), and (b) between 0.5% and 4% serum, such that the recombinant viral vectors are produced.

L'invention concerne des compositions et des procédés permettant d'augmenter la production d'un vecteur viral de recombinaison dans une culture cellulaire, consistant à réaliser une culture d'un vecteur viral de recombinaison produisant une ligne cellulaire dans un milieu basal qui comprend (a) plus de 1,5 g/L d'acides aminés (ou, une quantité d'un acide aminé sélectionné, par exemple un DMEM, supérieure à celle contenue dans le milieu basal), et (b) entre 0,5 % et 4 % de sérum, de manière à produire les vecteurs viraux de recombinaison.

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