Methods for in vivo t cell activation by antigen-pulsed...

Details Methods for in vivo t cell activation by antigen-pulsed... Methods for in vivo t cell activation by antigen-pulsed...

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 39/00 (2006.01) C07K 16/42 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2192655

The present invention relates to methods of using isolated human dendritic cells to present exogenous antigens for the induction of immune responses in vivo. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to lymphoma-derived immunoglobulins as antigens, and re-infusing the autologous antigen-pulsed dendritic cells into lymphoma patients to induce and/or augment a tumor-reactive immune response. The methods of the invention described herein have a wide range of applications, including but not limited to, the clinical use of antigen-pulsed dendritic cells as vaccines and/or immunotherapeutics against cancer and infectious agents such as viruses.

Cette invention se rapporte à des procédés d'utilisation de cellules dendritiques humaines isolées afin d'obtenir une présentation d'antigènes exogènes destinés à induire des réponses immunitaires in vivo. Cette invention se rapporte en particulier à des techniques pour isoler des cellules dendritiques du sang humain, pour exposer ces cellules à des immunoglobulines dérivées de lymphomes, ces immunoglobulines servant d'antigènes, et pour réinjecter les cellules dendritiques à impulsions antigèniques autologues dans le corps de patients souffrant de lymphones, afin de produire et/ou d'augmenter la réponse immunitaire en réaction à la tumeur. Les procédés décrits dans cette invention ont une large gamme d'applications, y compris notamment l'utilisation clinique des cellules denditriques à impulsions antigèniques comme vaccins et/ou comme moyens immunothérapeutiques contre le cancer et les agents infectieux tels que les virus.

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