Methods for increasing analgesic potency and attenuating...

Details Methods for increasing analgesic potency and attenuating... Methods for increasing analgesic potency and attenuating...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61K 31/215 (2006.01) A61K 33/00 (2006.01) A61K 38/33 (2006.01)

Patent

CA 2441889

The present invention provides a method for increasing analgesic potency of a bimodally-acting opioid agonist in a subject, by inhibiting GM1-ganglioside in nociceptive neurons. The present invention further provides a method for treating pain in a subject in need of treatment thereof. Also provided in the present invention is a method for treating chronic pain in a subject in need of treatment thereof. Additionally, the present invention provides a method for treating tolerance to or an addiction to a bimodally-acting opioid agonist in a subject in need of treatment thereof. Finally, the present invention provides a pharmaceutical composition of analgesic agents and a pharmaceutically-acceptable carrier.

L'invention concerne un procédé permettant d'augmenter l'activité analgésique d'un agoniste opioïde agissant de façon bimodale chez un sujet, par inhibition du ganglioside GM1 dans les neurones nociceptifs. L'invention concerne également une méthode de traitement de la douleur chez un sujet ayant besoin d'un tel traitement. En outre, l'invention concerne une méthode de traitement de douleurs chroniques chez un sujet ayant besoin d'un tel traitement. Par ailleurs, l'invention concerne une méthode de traitement de la tolérance ou de l'accoutumance à un agoniste opioïde agissant de façon bimodale chez un sujet ayant besoin d'un tel traitement. Enfin, l'invention concerne une composition pharmaceutique d'agents analgésiques et un excipient pharmaceutiquement acceptable.

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