Methods for increasing hematopoietic cells

Details Methods for increasing hematopoietic cells Methods for increasing hematopoietic cells

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2223046

Methods for increasing hematopoietic cells, including platelets and erythrocytes, in patients receiving bone marrow or peripheral blood stem cell transplants are disclosed. The methods comprise administering to a donor an amount of thrombopoietin sufficient to stimulate proliferation of cells of the myeloid lineage, collecting cells from the donor, and administering the collected cells to a recipient patient. The recipient patient may be treated with additional thrombopoietin. The methods are useful within allogeneic and autologous transplantation procedures.

La présente invention concerne des procédés d'augmentation du nombre de cellules hématopoïétiques, y compris les plaquettes et les érythrocytes, chez les patients qui reçoivent de la moëlle osseuse ou des greffes de cellules souches de sang périphérique. Ces procédés comprennent l'administration à un donneur d'une quantité de thrombopoïétine suffisante pour stimuler la prolifération de cellules de la lignée myéloïde, le prélèvement de cellules sur le donneur et leur administration à un patient receveur, qui peut être traité avec de la thrombopoïétine supplémentaire. Lesdits procédés sont utiles dans les procédures de greffes allogéniques et autologues.

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