Methods for increasing protein polyethylene glycol (peg)...

Details Methods for increasing protein polyethylene glycol (peg)... Methods for increasing protein polyethylene glycol (peg)...

C - Chemistry, Metallurgy

07

K

C07K 14/21 (2006.01)

Patent

CA 2560259

The present invention relates to highly conjugated proteins and methods for making such protein. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.

La présente invention concerne des protéines hautement conjuguées et des méthodes de fabrication de ces protéines. Plus particulièrement, la présente invention concerne des méthodes destinées à lier des sites additionnels à une protéine en vue d'une conjugaison avec des lieurs de polyéthylène glycol (PEG) activés, sans dénaturation de la protéine. L'invention se rapporte en outre à des protéines hautement conjuguées présentant une immunogénicité réduite et une demi-vie accrue dans la circulation.

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