C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C12N 15/01 (2006.01)
Patent
CA 2710439
The present invention relates to methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies, immunoglobulin G class 3 (IgG3) antibodies with an improved therapeutic efficacy and the use thereof as a medicament, in particularly a medicament for immunotherapy. Specifically, the present invention relates to methods for increasing the therapeutic efficacy of an immunoglobulin G class 3 (IgG3) antibody comprising providing a mutated immunoglobulin G class 3 (IgG3) antibody, wherein the mutation, as compared to the parent immunoglobulin G class 3 (IgG3) antibody, comprises a replacement of the amino acid arginine (R) at position 435 in the C H 3 domain with the amino acid histidine (H), and antibodies obtained by the present methods and their use as a medicament.
La présente invention concerne des procédés destinés à accroître l'efficacité thérapeutique d'anticorps immunoglobulines G de classe 3 (IgG3), des anticorps immunoglobulines G de classe 3 (IgG3) avec une efficacité thérapeutique améliorée et leur utilisation en tant que médicament, en particulier en tant que médicament pour l'immunothérapie. Spécifiquement, la présente invention concerne des procédés destinés à accroître l'efficacité thérapeutique d'un anticorps immunoglobuline G de classe 3 (IgG3) comprenant la fourniture d'un anticorps immunoglobuline G de classe 3 (IgG3) muté, la mutation, par rapport à l'anticorps immunoglobuline G de classe 3 (IgG3) parent, comprenant un remplacement de l'acide aminé arginine (R) à la position 435 dans le domaine CH3 par l'acide aminé histidine (H), et les anticorps obtenus par les présents procédés ainsi que leur utilisation en tant que médicament.
Van Der Schoot Catherine Elisabeth
Vidarsson Gestur
Gowling Lafleur Henderson Llp
Stichting Sanquin Bloedvoorziening
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