Methods for indentifying specifically cleavable peptides and...

Details Methods for indentifying specifically cleavable peptides and... Methods for indentifying specifically cleavable peptides and...

G - Physics

01

N

G01N 33/68 (2006.01) A61K 38/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2420065

The invention relates to methods for detecting and identifying peptides that can be specifically cleaved, using a defined amino acid sequence based on a library of nucleic acid peptide fusion molecules. According to said methods, the variable part of the peptides is coded by the respective nucleic acid fused thereto, using proteolytically active solutions. The invention also relates to the use of said peptides for diagnosis.

L'invention concerne un procédé permettant de détecter et d'identifier des peptides de fission spécifique par une séquence d'acides aminés définie sur la base d'une bibliothèque de molécules de fusion acide nucléique-peptide. La fraction variable des peptides est codée par l'acide nucléique, avec lequel elle est respectivement fusionnée, à l'aide de solutions d'action protéolytique. L'invention concerne également l'utilisation de ces peptides pour la libération ciblée de principes actifs chimiques et aux fins de diagnostic.

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