Methods for inducing an immune response with an elevated...

A - Human Necessities – 61 – K

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A61K 39/35 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/715 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2451479

The present invention provides a method of increasing the TH1:TH2 ratio of an immune response, comprising the step of supplying to an antigen presenting cell (APC) such as a dendritic cell (DC) or precursor cell, an intracellular activator of A-PC, such as DC, function. The invention also provides a method of treating a patient with or at risk of allergy comprising the step of supplying an intracellular activator of A-PC, such as DC, function, or an intracellular inducer of NF.kappa.B, to the patient or to an APC, such as a DC, or precursor cell, of the patient.

La présente invention concerne un procédé qui permet d'augmenter le rapport T¿H1? :T¿H2? d'une réaction immunitaire, selon lequel on confère à une cellule présentatrice d'antigène (APC) telle qu'une cellule dendritique (DC) ou un précurseur, une fonction d'activateur intracellulaire d'une APC telle qu'une cellule dendritique. L'invention concerne également un procédé permettant de traiter un patient souffrant ou risquant de souffrir d'une allergie, selon lequel on confère une fonction d'activateur intracellulaire d'une APC telle qu'une cellule dendritique, ou un inducteur intracellulaire de NF.kappa.B au patient ou à une APC telle qu'une cellule dendritique, ou à un précurseur dudit patient.

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