Methods for inducing angiogenesis using morphogenic proteins...

Details Methods for inducing angiogenesis using morphogenic proteins... Methods for inducing angiogenesis using morphogenic proteins...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 9/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2402586

The present invention provides a method for inducing angiogenesis at a target locus in a mammal using morphogenic proteins. In addition, this invention also features a method for improving the angiogenic capability of a morphogenic protein at a target locus in a mammal. In this method, the morphogenic protein is capable of inducing angiogenesis when accessible to a progenitor cell in the mammal, and the morphogenic protein stimulatory factor enhances that capability. The morphogenic protein and morphogenic protein stimulatory factor can be administered simultaneously to the target locus. Alternatively, the two components are administered separately, in any order.

La présente invention porte sur un procédé visant à induire l'angiogenèse au niveau d'un locus cible chez un mammifère au moyen de protéines morphogéniques. Cette invention porte également sur un procédé visant à améliorer la capacité angiogénique d'une protéine morphogénique au niveau d'un locus cible chez un mammifère. Dans ce procédé, la protéine morphogénique est capable d'induire l'angiogenèse lorsqu'elle est accessible à une cellule progénitrice du mammifère, le facteur de stimulation de la protéine morphogénique pouvant être administré simultanément sur le locus cible. En variante, le deux composants sont administrés simultanément, dans n'importe quel ordre.

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