C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2551920
The present invention provides methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts, and methods for identifying a compound that induces differentiation of undifferentiated mammalian cells into osteoblasts. In addition, the present invention provides polynucleotides and vectors, and the use thereof as a medicament for the treatment of a disease involving a systemic or local decrease in mean bone density. Moreover, the present invention provides methods for in vitro production of bone tissue, osteoblast cells and methods for diagnosing a pathological condition involving a systemic or local decrease in mean bone density or a susceptibility to the condition.
L'invention concerne des méthodes d'induction de la différenciation de cellules de mammifères non différenciées en ostéoblastes, et des méthodes d'identification d'un composé qui induit la différenciation de cellules de mammifère non différenciées en ostéoblastes. De plus, l'invention concerne des polynucléotides et des vecteurs, et leur utilisation en tant que médicament pour le traitement d'une maladie impliquant une réduction systémique ou locale de la densité osseuse moyenne. L'invention porte également sur des méthodes de production in vitro de tissu osseux, de cellules ostéoblastes et sur des méthodes de diagnostic d'un état pathologique impliquant une réduction systémique ou locale de la densité osseuse moyenne ou d'une réceptivité audit état.
Brown Robin John
Tomme Peter Herwig Maria
Van Rompaey Luc Juliaan Corina
Galapagos N.v.
Gowling Lafleur Henderson Llp
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