A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 35/14 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 41/00 (2006.01) A61M 1/36 (2006.01)
Patent
CA 2249412
The present invention provides improved methods for extracorporeal blood treatment, such as photochemotherapy, and related compositions are provided. The improved method involves introducing dendritic cells into the extracorporeal blood stream during agent treatment to further enhance the subject's immune system response to antigens present in the peripheral blood. The present invention further provides methods of identifying agents for use in the extracorporeal treatment of blood based on the ability of the agent to increase MHC expression.
La présente invention concerne des perfectionnements de procédés de traitement extracorporel du sang et notamment la photochimiothérapie. L'invention concerne également les compositions ad-hoc. Le procédé issu du perfectionnement consiste à introduire des cellules dendritiques dans le flux de circulation sanguine extracorporelle pendant le traitement par l'agent thérapeutique pour accroître la réponse du système immunitaire du sujet aux antigènes présents dans le sang périphérique. L'invention concerne enfin des procédés d'identification d'agents thérapeutiques utilisables pour le traitement extracorporel du sang en utilisant l'aptitude de l'agent thérapeutique à accroître l'expression des peptides MHC.
Deeth Williams Wall Llp
Yale University
LandOfFree
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