A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/39 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2494870
The invention provides methods for detecting and inhibiting angiogenesis, endothelial cell adhesion, and endothelial cell migration using agents which inhibit the specific binding of integrin .alpha.4.beta.1 to one or more of its ligands. The invention further provides methods for screening test compounds for their ability to inhibit angiogenesis, endothelial cell adhesion, or endothelial cell migration by employing agents which inhibit the specific binding of integrin .alpha.4.beta.1 to one or more of its ligands. The invention additionally relates to methods for isolating endothelial progenitor cells which express integrin .alpha.4.beta.1. The methods of the invention are useful in, for example, diagnosing and inhibiting pathological conditions that are associated with angiogenesis, endothelial cell adhesion, and/or endothelial cell migration. The invention's methods are also useful in isolating endothelial progenitor cells, and in determining the mechanisms that underlie angiogenesis, development, wound healing, and the function of the female reproductive system.
La présente invention concerne des procédés permettant la détection et l'inhibition de l'angiogenèse, l'adhésion des cellules endothéliales, et la migration des cellules endothéliales au moyen d'agents d'inhibition de la liaison spécifique de l'intégrine .alpha.4.beta.1 à un ou plusieurs de ses ligands. L'invention concerne également des procédés permettant le criblage de composés de test pour leur capacité d'inhibition de l'angiogenèse, l'adhésion ces cellules endothéliales, ou la migration des cellules endothéliales au moyen de ces agents d'inhibition de la liaison spécifique de l'intégrine .alpha.4.beta.1 à un ou plusieurs de ses ligands. L'invention concerne en outre des procédés permettant l'isolement des cellules souches exprimant l'intégrine .alpha.4.beta.1. Les procédés de l'invention sont également utiles dans l'isolement des cellules endothéliales souches, et dans la détermination des mécanismes qui sous-tendent l'angiogenèse, son développement, la cicatrisation, et la fonction du système de reproduction de la femme.
Smart & Biggar
The Regents Of The University Of California
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