Methods for inhibiting bone loss with 3,4-diarylchroman

Details Methods for inhibiting bone loss with 3,4-diarylchroman Methods for inhibiting bone loss with 3,4-diarylchroman

A - Human Necessities

61

K

A61K 31/35 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2157879

Methods and pharmaceutical compositions for reducing bone loss are disclosed. 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment of bone loss due to osteoporosis or other conditions. An exemplary 3,4- diarylchroman is centchroman (3,4-trans-2,2-dimethyl-3phenyl-4-(p-(beta-pyrrolidinoethoxy) phenyl]-7-methoxy-chroman). Formulations include tablets and other forms suitable for administration and controlled-release subdermal implants.

Procédés et préparations pharmaceutiques permettant de réduire les pertes osseuses. Les 3,4-diarylchromannes et leur sels pharmacocompatibles sont formulés pour servir de médicaments traitant les pertes osseuses résultant de l'ostéoporose et d'autres états. Un exemple de 3,4-diarylchromanne est représenté par le centchromane (3,4-trans-2,2-diméthyl-3-phényl-4-[p-(bêta-pyrrolidinoéthoxy)phényl]-7-méthoxy-chromanne). Les formulations décrites se présentent sous forme de comprimés ou autres présentations à administration orale, et d'implants sous-cutanés à diffusion contrôlée.

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