Methods for inhibiting decrease in transdermal drug flux by...

A - Human Necessities – 61 – K

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Details

A61K 9/70 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2422200

This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co- delivering or co-sampling the agent with an amount of at least one anti- healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).

Cette invention a trait à un procédé permettant d'enrayer une diminution de l'écoulement par voie transdermique d'un agent administré ou échantillonné par voie transdermique pendant un laps de temps prolongé. L'administration ou l'échantillonnage de l'agent suppose la rupture d'au moins la couche cornée de l'épiderme afin de ménager des passages pour ledit agent. On obtient ce résultat en administrant ou en échantillonnant l'agent en même temps qu'une certaine quantité d'au moins une substance empêchant la régénération tissulaire. Cet apport d'une certaine quantité de substance empêchant la régénération tissulaire permet d'enrayer efficacement la diminution de l'écoulement par voie transdermique de l'agent à la différence de ce qu'il en est lorsque l'on administre ou échantillonne cet agent dans des conditions sensiblement identiques mais sans apport d'une ou de plusieurs substances empêchant la régénération tissulaire.

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