A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4412 (2006.01) A61K 31/137 (2006.01) A61K 31/44 (2006.01) A61K 31/4415 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 39/06 (2006.01)
Patent
CA 2347117
The instant invention provides compositions and methods for modeling post- Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also teaches methods to treat or prevent diabetes associated hyperlipidemia, cellular redox imbalances, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis, comprising administering the compounds of the invention to a mammal in need thereof.
La présente invention concerne des compositions et des procédés de modélisation de la formation de produits terminaux de glycosylation avancée (AGE) post-Amadori, ces procédés permettant par ailleurs d'identifier et de caractériser des inhibiteurs efficaces de cette formation de produits AGE post-Amadori. Cette invention concerne également les compositions d'inhibition ainsi identifiées, ainsi que les procédés permettant de traiter ou de prévenir l'hyperlipidémie, les déséquilibres d'oxydoréduction cellulaire, l'hypercholestérolémie, l'hypertriglycéridémie, et l'athérosclérose liés au diabète, ces procédés consistant notamment à administrer les composés de cette invention à un mammifère nécessitant un tel traitement.
Alderson Nathan
Baynes John W.
Degenhardt Thorsten P.
Hudson Billy
Khalifah Raja Gabriel
Kansas University Medical Center Research Institute Inc.
Mbm Intellectual Property Law Llp
University Of South Carolina
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