Methods for inhibiting drug degradation

Details Methods for inhibiting drug degradation Methods for inhibiting drug degradation

C - Chemistry, Metallurgy

07

D

C07D 307/79 (2006.01) A61K 31/343 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61P 31/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2716349

Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of dis-eases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Linvention concerne des procédés pour inhiber des enzymes P450 de cytochrome qui peuvent être utilisés pour améliorer le traitement de maladies par prévention de la dégradation de médicaments ou dautres molécules par le P450 de cytochrome. Des compositions pharmaceutiques qui peuvent agir comme intensificateurs pour améliorer la pharmacocinétique, amplifier la biodisponibilité et leffet thérapeutique de médicaments qui subissent une dégradation in vivo par des enzymes P450 de cytochrome sont proposées.

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