Methods for inhibiting neurofibromatosis type 1 (nf1)

Details Methods for inhibiting neurofibromatosis type 1 (nf1) Methods for inhibiting neurofibromatosis type 1 (nf1)

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/352 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2388343

A method is provided to identify inhibitors of any one of Raf, MEK, extracellular signal regulated kinase 1 (ERK1), extracellular signal regulated kinase 2 (ERK2), phosphatidylinositol triphosphate kinase (PI3K), p21 activated kinase 2 (PAK2), p21 activated kinase 3 (PAK3), Rac, CDC42, p21 activated kinase 1 (PAK1), protein kinase B (PKB), Akt, and c-jun N-terminal kinase (JNK), or crosstalk between the PI3-K an the Ras-Raf-MEK-ERK pathway, useful to treat disorders such as neurofibromatosis type 1 or at least one clinical manifestation thereof.

La présente invention concerne une méthode pour identifier les inhibiteurs de Raf, MEK, protéine ERK1, protéine ERK2, phosphatidylinositol triphosphate kinase (P13K), protéine PAK2, protéine PAK3, Rac, CDC42, protéine PAK1, protéine kinase B (PKB), Akt, de c-protéine JNK, ou du couplage parasite entre P13-K et le trajet Ras-Raf-MEK-ERK, utilisés pour traiter les troubles tels que la neurofibromatose de type 1, ou au moins un de ses signes cliniques.

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