Methods for inhibiting or reversing tau filament fibrillization

Details Methods for inhibiting or reversing tau filament fibrillization Methods for inhibiting or reversing tau filament fibrillization

A - Human Necessities

61

K

A61K 31/425 (2006.01)

Patent

CA 2529854

Methods for inhibiting and/or reversing tau filament formation or fibrillization are provided. These methods can be used for treating certain neurological disorders in vivo by administering pharmaceutical compositions which inhibit and/or reverse tau filament formation or fibrillization. A preferred composition comprises 3-(2-hydroxyethyl)-2-[2-[[3-(2-hydroxyethyl)-5- methoxy-2-benzothiazolylidene]methyl]-1-butenyl]-5-methoxybenzothiazolium.

La présente invention concerne des procédés permettant d'inhiber ou d'inverser la formation de fibrilles ou filaments de protéine tau. Ce procédé convient au traitement in vivo de certains troubles neurologiques. Il consiste en l'administration de compositions pharmaceutiques inhibant et/ou inversant la formation de fibrilles ou filaments de protéine tau. L'une de ces compositions préférées comprend du 3-(2-hydroxyéthyl)-2-[2-[[3-(2-hydroxyéthyl)-5-méthoxy-2-benzothiazolylidène]méthyl]-1-butényl]-5-méthoxybenzothiazolium.

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