A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) A61K 31/00 (2006.01) A61K 31/195 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01)
Patent
CA 2455969
Methods for inhibiting and/or reversing tau filament formation or polymerization are provided. These methods can be used for treating certain neurological disorders in vivo by administering pharmaceutical compositions which inhibit and/or reverse tau filament formation or polymerization. An especially preferred pharmaceutical composition contains an inhibitor of the general formula (I), wherein R1 is an aliphatic radical having one to six carbon atoms and wherein R2 and R3 independently are a second aliphatic radical having one to six carbon atoms, a hydroxyl-substituted aliphatic radical having one to six carbon atoms, or a pheny radical or a pharmaceutically acceptable salt of the inhibitor.
Procédés visant à inhiber et/ou à inverser le processus de formation de filaments tau ou polymérisation. Ces procédés peuvent servir à traiter certains troubles neurologiques <i>in vivo</i>, par l'administration de compositions pharmaceutiques qui inhibent et/ou inversent le processus de formation de filaments tau ou polymérisation. Une composition pharmaceutique particulièrement préférée contient : un inhibiteur représenté par la formule générale (I), dans laquelle R¿1? représente un radical aliphatique possédant de un à six atomes de carbone, et R¿2? et R¿3? représentent indépendamment un deuxième radical aliphatique possédant de un à six atomes de carbone, un radical aliphatique à substitution hydroxyle possédant de un à six atomes de carbone ou un radical phény ; ou un sel pharmaceutiquement acceptable de l'inhibiteur.
Khatami Sam
Kuret Jeff
Macrae & Co.
Neuronautics Inc.
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