C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61P 25/28 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2466334
The present invention provides methods for inhibiting proliferation of astrocytes and astrocytic tumor cells. The present invention further provides methods for treating a condition associated with a defect in astrocyte proliferation in a subject, and methods for treating a condition associated with astrocytic tumor cell proliferation in a subject. Additionally, the present invention discloses methods for enhancing survival of neurons. The present invention still further provides methods for treating neural degeneration in a subject. The present invention is also directed to pharmaceutical compositions, comprising NrS1 protein or nucleic acid and a pharmaceutically-acceptable carrier. Finally, the present invention provides a purified NrS1 protein, an agent that binds to the NrS1 protein, a kit comprising an agent that binds to the NrS1 protein, and a composition comprising the NrS1 protein and a carrier.
L'invention concerne des procédés servant à inhiber la prolifération des astrocytes et des cellules tumorales astrocytiques. Elle concerne, de plus, des procédés servant à traiter un état associé à un défaut de la prolifération des astrocytes chez un sujet, ainsi que des procédés servant à traiter un état associé à la prolifération des cellules tumorales astrocytiques chez ce sujet. Elle concerne également des procédés servant à augmenter la survie des neurones. Elle concerne également des procédés servant à traiter la dégénérescence neuronale chez un sujet. Elle concerne également des compositions pharmaceutiques contenant la protéine NrS1 ou un acide nucléique et un véhicule acceptable sur le plan pharmaceutique. Elle concerne enfin une protéine NrS1 purifiée, un agent se liant à cette protéine NrS1, une trousse contenant un agent se liant à la protéine NrS1 et une composition contenant cette protéine NrS1 et un véhicule.
Suarez Carlos
Weinstein David E.
Zerlin Marielba
Albert Einstein College Of Medicine Of Yeshiva University
Gowling Lafleur Henderson Llp
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